解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occur...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12943
更新日期:2018-03-01 00:00:00
abstract::There is strong evidence of a key role for mitochondrial dysfunction in both sporadic and all forms of familial Parkinson's disease (PD). However, none of the clinical trials carried out with putative mitochondrial rescue agents have been successful. Firm establishment of a wet biomarker or a reliable readout from ima...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12920
更新日期:2018-03-01 00:00:00
abstract::Oxidative stress and an increase in the levels of free radicals are important markers associated with several pathologies, including Alzheimer's disease, cancer and diabetes. Friedreich's ataxia (FRDA) is an excellent paradigmatic example of a disease in which oxidative stress plays an important, albeit incompletely u...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12928
更新日期:2018-03-01 00:00:00
abstract::Heme is essential and synthesized via highly regulated processes. For this reason, most organisms strive to recycle it or acquire it from their environment. When heme is bound to proteins noncovalently, degradation of the polypeptide is sufficient to release it. However, in some hemoproteins, such as c-type cytochrome...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.13006
更新日期:2018-03-01 00:00:00
abstract::Genome maintenance and integrity requires continuous alterations of the compaction state of the chromatin structure. Chromatin remodelers, among others the INO80 complex, help organize chromatin by repositioning, reshaping, or evicting nucleosomes. We report on INO80 nucleosome remodeling, assayed by single-molecule F...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12973
更新日期:2018-02-01 00:00:00
abstract::Redox homeostasis is a prerequisite for survival of the pathogen Mycobacterium tuberculosis (Mtb) which employs the low molecular weight thiol mycothiol (MSH). The Mycobacterial NADPH-dependent mycothione reductase (MtMtr), composed of an NADPH-, FAD-, and a dimerization-domain connected by linkers, regulates the bala...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12984
更新日期:2018-02-01 00:00:00
abstract::Transactive response DNA-binding protein of 43 kDa (TDP-43) regulates RNA processing, including alternative splicing of tau exon 10. Pathological TDP-43 is hyperphosphorylated. However, how do the protein phosphatase(s) (PP) regulate TDP-43 phosphorylation is unclear. Here, we found that both PP1 and PP2A were coimmun...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12976
更新日期:2018-02-01 00:00:00
abstract::The plant-specific GAI-RGA-and-SCR (GRAS) family of proteins function as transcriptional regulators and play critical roles in development and signalling. Recent structural studies have shed light on the molecular functions at the structural level. The conserved GRAS domain comprises an α-helical cap and α/β core subd...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12987
更新日期:2018-02-01 00:00:00
abstract::Increasingly available genomic sequencing data are exploited to identify genes and variants contributing to diseases, particularly cancer. Traditionally, methods to find such variants have relied heavily on allele frequency and/or familial history, often neglecting to consider any mechanistic understanding of their fu...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12988
更新日期:2018-02-01 00:00:00
abstract::Nucleoside modifications in tRNA anticodons regulate ribosome dynamics during translation elongation and, thereby, fine-tune global protein synthesis rates. The highly conserved eukaryotic Elongator complex conducts specific C5-substitutions in tRNA wobble base uridines. It harbors two copies of each of its six indivi...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12865
更新日期:2018-02-01 00:00:00
abstract::Activation-induced cytidine deaminase (AID), a member of the APOBEC family that induces antibody diversification, has been shown to inhibit the replication of hepatitis B virus, Kaposi's sarcoma-associated herpesvirus, and retro-transposons. However, whether AID can inhibit human immunodeficiency virus 1 (HIV-1) repli...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12954
更新日期:2018-01-01 00:00:00
abstract::Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the ra...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12941
更新日期:2018-01-01 00:00:00
abstract::Focal adhesion (FA) proteins, kindlin-2 and integrin-linked kinase (ILK), regulate cell adhesion and migration. ILK interacts with and promotes kindlin-2 targeting to FAs. Leu353 and Leu357 in kindlin-2 have been reported to be important for the interaction between kindlin-2 and ILK. However, the binding interface bet...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12938
更新日期:2018-01-01 00:00:00
abstract::Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis. Here, we demonstrate that Cripto-1 expression is regulated by OCT4 in human embryonic carcinoma NCCIT cells. The endogenous expression of Cripto-1 and OCT4 is significantly reduced during differentiation. Cripto-1 expression...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12935
更新日期:2018-01-01 00:00:00
abstract::Macrophages are abundant in the tumor microenvironment. They are highly plastic and able to acquire pro-tumoral phenotypes in response to microenvironmental stimuli. When we treated RAW 264.7 macrophages with inhibitors of various oncogenic pathways, we found that the focal adhesion kinase (FAK) inhibitors PF573228 an...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12895
更新日期:2017-12-01 00:00:00
abstract::The archaeal exosome, a protein complex responsible for phosphorolytic degradation and tailing of RNA, has an RNA-binding platform containing Rrp4, Csl4, and DnaG. Aiming to detect novel interaction partners of the exosome, we copurified Nop5, which is a part of an rRNA methylating ribonucleoprotein complex, with the ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12915
更新日期:2017-12-01 00:00:00
abstract::Aquaporin-4, a predominant water channel in the central nervous system, has two isoforms, M1 and M23, whose transcripts are driven by distinct promoters. Using a reporter assay, we found that a fragment located between exons 0 and 1 of the mouse aquaporin-4 gene, which had been thought to be the promoter for M23, lack...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12910
更新日期:2017-12-01 00:00:00
abstract::Buthionine sulfoximine (BSO) induces decreased glutathione (GSH) and trypanothione [T(SH)2 ] pools in trypanosomatids, presumably because only gamma-glutamylcysteine synthetase (γECS) is blocked. However, some BSO effects cannot be explained by exclusive γECS inhibition; therefore, its effect on the T(SH)2 metabolism ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12904
更新日期:2017-12-01 00:00:00
abstract::Respiratory supercomplex factor (Rcf) 1 is a membrane-bound protein that modulates the activity of cytochrome c oxidase (CytcO) in Saccharomyces cerevisiae mitochondria. To investigate this regulatory mechanism, we studied the interactions of CytcO with potassium cyanide (KCN) upon removal of Rcf1. While the addition ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12918
更新日期:2017-12-01 00:00:00
abstract::G-quadruplex structures in the 5' UTR of mRNAs have been shown to suppress translation. However, all experiments published so far made use of artificial reporter systems. Here, we investigate for the first time the biological effects of the genomic disruption of a G-quadruplex by CRISPR/Cas9. In melanoma cells lacking...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12855
更新日期:2017-11-01 00:00:00
abstract::Protein kinase A (PKA) signaling is essential for growth and virulence of the fungal pathogen Aspergillus fumigatus. Little is known concerning the regulation of this pathway in filamentous fungi. Employing liquid chromatography-tandem mass spectroscopy, we identified novel phosphorylation sites on the regulatory subu...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12886
更新日期:2017-11-01 00:00:00
abstract::Immunometabolism focuses on the mechanisms regulating the impact of metabolism on lymphocyte activity and autoimmunity outbreak. The adipose tissue is long known to release adipokines, either pro- or anti-inflammatory factors bridging nutrition and immune function. More recently, adipocytes were discovered to also rel...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12733
更新日期:2017-10-01 00:00:00
abstract::T cells are stimulated by the engagement of antigen, cytokine, pathogen, and hormone receptors. While research performed over many years has focused on deciphering the molecular components of these pathways, recent data underscore the importance of the metabolic environment in conditioning responses to receptor engage...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12849
更新日期:2017-10-01 00:00:00
abstract::Proteins may undergo adaptive structural transitions to accommodate to their cellular milieu and respond to external signals. Modulation of conformational ensembles can rewire the intra- or intermolecular interaction networks and shift between different functional states. Adaptive conformational transitions are associ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12762
更新日期:2017-09-01 00:00:00
abstract::The H-Ras-like suppressor (HRASLS) is a protein family consisting of five members in humans. Despite their discovery as tumor suppressors, we demonstrated that all these proteins are phospholipid-metabolizing enzymes, such as phospholipase (PL) A1 /A2 and acyltransferase. We thus proposed to rename HRASLS1-5 as PLA/ac...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12787
更新日期:2017-09-01 00:00:00
abstract::Translocation of folded proteins by the Tat system of Escherichia coli is believed to rely on the presence of phosphatidylethanolamine (PE) and the negatively charged phospholipids cardiolipin (CL) and phosphatidylglycerol (PG). Here, we show that while PE is indeed essential for activity, the Tat system is fully func...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12794
更新日期:2017-09-01 00:00:00
abstract::Rab5 GTPases are master regulators of early endosome biogenesis and transport. The genome of Saccharomyces cerevisiae encodes three Rab5 proteins: Vps21, the major isoform, Ypt52 and Ypt53. Here, we show that Vps21 is the most abundant Rab5 protein and Ypt53 is the least abundant. In stressed cells, Ypt53 levels incre...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12785
更新日期:2017-09-01 00:00:00
abstract::Golgin45 plays important roles in Golgi stack assembly and is known to bind both the Golgi stacking protein GRASP55 and Rab2 in the medial-Golgi cisternae. In this study, we sought to further characterize the cisternal adhesion complex using a proteomics approach. We report here that Acyl-CoA binding domain containing...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12780
更新日期:2017-09-01 00:00:00
abstract::Human preimplantation developmental studies are difficult to accomplish due to associated ethical and moral issues. Preimplantation cells are rare and exist only in transient cell states. From a single cell, it is very challenging to analyse the origination of the heterogeneity and complexity inherent to the human bod...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.12716
更新日期:2017-08-01 00:00:00
abstract::Modulation of intracellular guanosine 3',5'-bispyrophosphate ((p)ppGpp) level, the effector of the stringent response, is crucial for survival as well as optimal growth of prokaryotes and, thus, for bacterial pathogenesis and dormancy. In Mycobacterium tuberculosis (Mtb), (p)ppGpp synthesis and degradation are carried...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12739
更新日期:2017-08-01 00:00:00
abstract::Glucocorticoid-induced TNFR-related protein (GITR) is constitutively expressed in T regulatory (Treg) cells and regulates their suppressive function. We identified two methylated CpG islands in the Gitr locus. Using a ChIP assay, we demonstrate that both DNMT1 and methyl-CpG-binding domain Protein 4 (MBD4) bind to the...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12690
更新日期:2017-07-01 00:00:00
abstract::Numerous biological proteins exhibit intrinsic disorder at their termini, which are associated with multifarious functional roles. Here, we show the surprising result that an increased percentage of terminal short transiently disordered regions with enhanced flexibility (TstDREF) is associated with accelerated folding...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12725
更新日期:2017-07-01 00:00:00
abstract::The process of cell reprogramming has been characterized considerably since the successful generation of induced pluripotent stem cells. However, the importance of cell-cell communications for cellular reprogramming remains largely unknown. Secreted factors, which are expressed and secreted during reprogramming, may i...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12665
更新日期:2017-06-01 00:00:00
abstract::Mod5 is a multifunctional protein that modifies a subset of tRNAs in the cytoplasm and is also required for an RNA-mediated form of transcriptional silencing. Previous in vivo studies have shown that the nuclear silencing function of Mod5 does not require that the causative tRNA gene encode a Mod5 substrate, although ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12627
更新日期:2017-06-01 00:00:00
abstract::The heterogeneity of computationally predicted reaction fluxes in metabolic networks within a single flux state can be exploited to detect their significant flux backbone. Here, we disclose the backbone of Escherichia coli, and compare it with the backbones of other bacteria. We find that, in general, the core of the ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12650
更新日期:2017-05-01 00:00:00
abstract::Fatty acid synthase (Fasn) is a key component of energy metabolism that is dynamically induced by food intake. Although extensive studies have revealed a number of transcription factors involved in the fasting/refeeding transition of Fasn expression in hepatocytes, much less evidence is available for adipocytes. Using...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12620
更新日期:2017-04-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a prototypical proinflammatory cytokine that can elicit strong inflammation in macrophages by activating NF-κB. The underlying epigenetic mechanism is obscure. We show here that megakaryocytic leukemia 1 (MKL1) is an epigenetic mediator of TNF-α-induced proinflammatory transcript...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12601
更新日期:2017-03-01 00:00:00
abstract::Telomerase is an almost universal cancer target that consists minimally of a core protein human telomerase reverse transcriptase (hTERT) and a RNA component human telomerase RNA (hTR). Some inhibitors of this enzyme are thought to function by the covalent binding to one or several cysteine residues; however, this inhi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12589
更新日期:2017-03-01 00:00:00
abstract::In the lysosomal storage disorder Gaucher disease (GD), glucosylceramide (GlcCer) accumulates due to the defective activity of glucocerebrosidase. A subset of GD patients develops neuropathology. We now show mislocalization of Limp2-positive puncta and a large reduction in the number of Lamp1-positive puncta, which ar...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12591
更新日期:2017-03-01 00:00:00
abstract::Strigolactones are a new class of phytohormones synthesized from carotenoids via carlactone. The complex structure of carlactone is not easily deducible from its precursor, a cis-configured β-carotene cleavage product, and is thus formed via a poorly understood series of reactions and molecular rearrangements, all cat...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.12593
更新日期:2017-03-01 00:00:00